Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages

► Statins inhibit macrophage FABP4 expression by reducing cellular cholesterol levels. ► Dexamethasone induces macrophage FABP4 expression by activating pGRE in the gene. ► However, statins synergize dexamethasone-induced FABP4 expression. ► The synergistic induction is completed by enhancing GR translocation and inhibiting nGRE.