Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients

► We compared ezetimibe add-on to statin effects on lipids/non-cholesterol sterols. ► High-potency statin group (HPS) had lowest lathosterol/highest sitosterol at baseline. ► HPS + ezetimibe had the greatest absorption reduction/smallest synthesis increase. ► LDL-C lowering was similar for ezetimibe add-on to low-/medium-/high-potency statins. ► Results highlight complementary effect of statin + ezetimibe on synthesis/absorption.