Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study

► We assessed associations between herpesviruses and subclinical coronary atherosclerosis among HIV-infected men. ► Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging to evaluate coronary atherosclerosis. ► This is the first report suggesting herpes simplex virus type 2 (HSV-2) may be a risk factor for coronary atherosclerosis in HIV-infected men. ► Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.