Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm

► Genetic resemblance between abdominal aortic aneurysm and Marfan syndrome. ► TGFBR2 is subject to acquired copy number variations that might contribute to the pathogenesis of abdominal aortic aneurysm. ► TGFBR2 haploinsufficiency in abdominal aortic aneurysm.