کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5948886 1172382 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients
چکیده انگلیسی

BackgroundThe complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis.The aim of this study is to investigate whether levels of the complement are associated to the presence of subclinical atherosclerosis, lipid and glucose metabolism and inflammatory markers in SLE patients.MethodsSixty-nine consecutive patients with SLE were recruited for the study. Fasting venous blood samples were collected on the same day as the measurements of cIMT were performed. Total plasma lipids and the distribution of subclasses of lipoproteins were analyzed by nuclear magnetic resonance spectroscopy.ResultsWe found direct correlations between cIMT values and the levels of C3, C4 and CH50. In multivariate analyses, the mean cIMT from the three territories were predicted by age (β = 0.005, 95% CI: 0.002-0.007, P < 0.001) and the functional hemolytic assay of the complement activity CH50 (β = 0.003, 95% CI: 0.001-0.006, P < 0.0013). The complement components were associated with BMI, SBP and levels of glucose. Small, dense HDL particles also correlated with the three complement components C3, C4 and CH50 in bivariate analyses. In multivariate analyses small HDL particles predicted levels of C3: β = 0.024, 95% CI: 0.013-0.035, P < 0.001; and C4: β = 0.005, 95% CI: 0.002-0.008, P = 0.006.ConclusionsActivation of the complement system measured by functional assay CH50 is related to subclinical atherosclerosis in quiescent lupus patients and is activated by the small dense HDL particles.

► Complement system is associated with subclinical atherosclerosis in SLE patients. ► Small HDL particles predict levels of the complement components C3 and C4. ► Small HDL particles are pro-atherogenic in this population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 225, Issue 1, November 2012, Pages 224-230
نویسندگان
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