Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: Differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses

► Adiponectin suppresses foam cell transformation through AdipoR1, AdipoR2 and APPL1. ► AdipoR1 is required by adiponectin to suppress TNFα and MCP-1 gene expression. ► AdipoR2 is the dominant receptor to suppress SR-AI and upregulate IL-1Ra. ► APPL1 is required to inhibit SR-AI and NF-κB gene expression and Akt phosphorylation.