کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5949388 1172387 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The metabolic syndrome, atherosclerosis and cognitive functioning in a non-demented population: The Hoorn Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The metabolic syndrome, atherosclerosis and cognitive functioning in a non-demented population: The Hoorn Study
چکیده انگلیسی

BackgroundThe metabolic syndrome (MetS) is associated with cognitive deficits and atherosclerotic vascular disease. We examined whether the relation between the MetS and cognitive dysfunction is mediated by measures of atherosclerosis or the presence of clinically manifest cardiovascular disease.MethodsIn 380 individuals (153 with MetS; 60-87 years) from the population based Hoorn Study, measures of atherosclerosis including carotid intima-media thickness (c-IMT), flow mediated dilation (FMD), ankle-brachial index and the presence of clinically manifest cardiovascular disease were assessed at baseline and 7 later years at follow-up. Cognitive functioning (information processing speed, memory, and attention and executive functioning) was assessed at follow-up. The relation between the MetS, atherosclerosis and cognitive functioning was assessed with linear regression analysis.ResultsIndividuals with MetS showed worse performance on information processing speed (adjusted mean difference z-score ± SE: −0.22 ± 0.6; p = 0.01) and attention and executive functioning (−0.32 ± 0.07; p < 0.001), but not on the domain memory. The affected cognitive domains were also associated with measures of atherosclerosis (standardised B (95%CI) c-IMT: −0.14 (−0.24; −0.05); p < 0.01; FMD: 0.13 (0.02; 0.24), p < 0.05) and a history of clinically manifest cardiovascular disease: (−0.29 (−0.47; −0.11); p < 0.01). However, the relation between the MetS and cognitive functioning did not change after adjustment for c-IMT, FMD or a history of clinically manifest cardiovascular disease (p > 0.05).ConclusionIn this population based cohort, the relation between the MetS and cognitive dysfunction was not mediated by atherosclerosis or a history of cardiovascular disease. These findings should stimulate future studies to elucidate alternative mechanisms underlying cognitive deficits in individuals with MetS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 219, Issue 2, December 2011, Pages 839-845
نویسندگان
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