کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5949688 | 1172390 | 2011 | 5 صفحه PDF | دانلود رایگان |
ObjectiveRecent evidence suggests that amyloid precursor protein (APP) is overexpressed in atherosclerosis-prone regions of mouse aorta. We therefore investigated in the present study whether APP has a role in the progression and composition of atherosclerotic plaques.Methods and resultsApolipoprotein E-deficient (apoEâ/â) mice were crossbred with animals lacking APP (APPâ/â). After 16 weeks on a Western-type diet, apoEâ/â and APPâ/â/apoEâ/â mice showed similar cholesterol levels. However, atherosclerotic plaque size was significantly reduced in the distal thoracic aorta (90% reduction) and abdominal aorta (75% reduction) of APPâ/â/apoEâ/â mice as compared to apoEâ/â. Plaques at the level of the aortic valves were not different in size, but showed a more stable phenotype in APPâ/â/apoEâ/â mice, as indicated by a reduced macrophage content, an increased amount of collagen and a thicker fibrous cap.ConclusionOur findings provide evidence that lack of APP attenuates atherogenesis and leads to plaque stability.
Journal: Atherosclerosis - Volume 216, Issue 1, May 2011, Pages 54-58