کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5950267 | 1172396 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
5â²-Nitro-indirubinoxime inhibits inflammatory response in TNF-α stimulated human umbilical vein endothelial cells
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کلمات کلیدی
ICAM-1HUVECMCP-1IL-8VCAM-1Interleukin-8 - اینترلوکین -8tumor necrosis factor-α - تومور نکروز عامل αTNF-α - فاکتور نکروز توموری آلفاintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1vascular cell adhesion molecule-1 - مولکول چسبندگی سلولی عروقی-1monocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Inflammation plays a critical role in the development of atherosclerosis and TNF-α, a major inflammatory cytokine, induces inflammatory responses by enhancing the expression of adhesion molecules and the secretion of inflammatory mediators. Indirubin is an active compound of Polygonum tinctorium Lour (P. tinctorium) that has the ability to suppress inflammation. Previously, we described the novel indirubin derivative, 5â²-nitro-indirubinoxime (5â²-NIO), and demonstrated that it has potent anti-proliferative activity against various human cancer cells. In this study, we examined the effect of 5â²-NIO on the TNF-α induced inflammatory conditions of human umbilical vein endothelial cells (HUVECs). We found that 5â²-NIO inhibited TNF-α induced MCP-1 and IL-8 expression at the RNA and protein levels in HUVECs. Specifically, 5â²-NIO significantly inhibited the TNF-α stimulated release of MCP-1 and IL-8, with levels that were only 19.8% and 30.9% of those of untreated control cells, respectively. Furthermore, 5â²-NIO largely inhibited the adhesion of U937 cells to HUVECs by decreasing the expression level of ICAM-1 and VCAM-1. Overall, these observations suggest that 5â²-NIO has the potential for use as an anti-atherosclerotic agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 211, Issue 1, July 2010, Pages 77-83
Journal: Atherosclerosis - Volume 211, Issue 1, July 2010, Pages 77-83
نویسندگان
Eun-Jung Kim, Won-Hwan Park, Sang-Gun Ahn, Jung-Hoon Yoon, Si-Wouk Kim, Soo-A Kim,