کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5950570 1172399 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy
چکیده انگلیسی

ObjectiveWe investigated whether statin-treated heterozygous familial hypercholesterolemic (FH) patients have lower plasma coenzyme Q10 (CoQ10) levels than low-density lipoprotein receptor (LDLR) mutation negative FH patients on equivalent statin doses, and whether lower CoQ10 concentrations are associated with increased arterial stiffness.MethodsThirty LDLR mutation negative patients with clinical FH and 30 mutation positive FH patients matched for gender, statin duration and dose, and a further 30 controls were studied. Plasma CoQ10 and asymmetric dimethylarginine (ADMA) levels were measured by HPLC and the augmentation index by pulse wave analysis.ResultsPlasma CoQ10 levels, and the ratios of CoQ10 to total cholesterol and LDL-cholesterol were similar in treated FH patients with identified LDLR mutations to mutation negative patients on equivalent doses of statin therapy (p > 0.05). CoQ10 and lipid levels were also comparable to controls not using any lipid modifying treatment. Arterial stiffness was higher in mutation negative patients (p = 0.04) and there was a trend for an increase in mutation positive patients (p = 0.09). ADMA was higher in the mutation positive group (p < 0.01). The augmentation index corrected for age, blood pressure, and heart rate, was negatively correlated with plasma CoQ10 within FH patients (p < 0.05).ConclusionLong-term, high-dose statin therapy does not lead to subnormal CoQ10 concentrations in patients with phenotypic or genotypic FH. Arterial stiffness is elevated in FH patients compared to untreated controls, and low CoQ10 levels are associated with increased arterial stiffness. CoQ10 supplementation trials are warranted in FH patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 218, Issue 1, September 2011, Pages 188-193
نویسندگان
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