کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5951316 | 1172413 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cathepsin K gene disruption does not affect murine aneurysm formation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Contrary to our expectations, catK deficiency did not protect against aneurysm formation, nor did it affect medial elastin breaks. Proteolytic activity in abdominal aortic lysates were comparable between apoEâ/â and catKâ//âapoEâ/â mice. Adventitial presence of catS- and catC-expressing cells was significantly increased in catKâ/â//apoEâ/â versus apoEâ/â mice, which might have compensated for the deficiency of catK-derived proteolysis in the aneurysm tissue of catK deficient apoEâ/â mice. Circulating granulocytes and activated T cell numbers were significantly increased in Ang II-infused catKâ/â//apoEâ/â mice, which is consistent with the borderline significant increase in adventitial leukocyte content in catKâ/â//apoEâ/â compared to apoEâ/â mice. Strikingly, despite unchanged proteolytic activity in AAA lesions, collagen content in the aneurysm was significantly increased in catKâ//âapoEâ/â mice. In conclusion, while catK deficiency has major impact on various vasculopathies, it did not affect murine aneurysm formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 209, Issue 1, March 2010, Pages 96-103
Journal: Atherosclerosis - Volume 209, Issue 1, March 2010, Pages 96-103
نویسندگان
Lili Bai, Linda Beckers, Erwin Wijnands, Suzanne P.M. Lutgens, M. Verónica HerÃas, Paul Saftig, Mat J.A.P. Daemen, Kitty Cleutjens, Esther Lutgens, Erik A.L. Biessen, Sylvia Heeneman,