کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
595473 | 1454022 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis
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کلمات کلیدی
Bacillus subtilisDPHPHENADPHL-phenylalaninePBS1,6-diphenyl-1,3,5-hexatriene - 1،6-دیفنیل-1،3،5-هگزیدریلEDTA - اتیلن دی آمین تترا استیک اسید ethylene diamine tetraacetic acid - اتیلن دیامین تتراستیک اسیدFatty acid composition - ترکیب اسید چربMembrane fluidity - سیالیت غشاییfatty acid methyl esters - متیل استرهای اسید چربFAME یا fatty acid methyl esters - متیل استرهای اسید چربphosphate buffer solution - محلول بافر فسفاتSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیScanning electronic microscope - میکروسکوپ الکترونیکی اسکن شدهnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphate
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis](/preview/png/595473.png)
چکیده انگلیسی
In this study the effects of houttuyfonate homologues (HOU-Cn) on the surface and shape, the lipid fluidity and the protein conformation, the fatty acid compositions and fatty acid synthase II (FAS II) of B. subtilis were studied to elucidate the antibacterial mechanism of HOU-Cn against Bacillus subtilis. The scanning electronic microscope (SEM) results showed that the glycocalyx on the surface of B. subtilis disappeared and the cell became smaller after being treated with HOU-Cn. During the co-incubation of HOU-Cn and B. subtilis, HOU-Cn was decomposed into alkyl acyl aldehyde and sodium sulfite rapidly. Then alkyl acyl aldehyde was congregated onto cell membrane and inserted into lipid bilayer, further increased the fluidity of membrane and changed the conformation of membrane protein by hydrophobic binding. Subsequently, HOU-Cn inhibited the FAS II activity, and decreased the synthesis of fatty acids, especially increased the percentage of saturated fatty acid. HOU-Cn showed a strong antibacterial activity against G+-bacteria by a multi-target antibacterial mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 350, Issues 1â3, 20 October 2009, Pages 130-135
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 350, Issues 1â3, 20 October 2009, Pages 130-135
نویسندگان
Xiaoli Ye, Li Xu, Xuegang Li, Zhu Chen, Baoshun Zhang, Lujiang Yuan, Xing Chen, Huajin Zhang, Wen Chang, Shengliang Sun,