Microarray spotting of nanoparticles

A method whereby controlled arrays of hexagonally ordered monolayer islands of polystyrene particles can be deposited using a microspotter was demonstrated. The microparticle size could be varied from the micrometer to the sub-micrometer size range and the island size from less than 10 μm in diameter and up, allowing for direct combination of microarray patterning and parallel nanopatterning of each array spot. The particle monolayer arrays are easily combined with other recent developments in particle lithography of particular interest for biosensor and biointerface screening arrays.