کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
595926 1454029 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Absorption of 10-hydroxycamptothecin into the coat of magnetoliposomes
چکیده انگلیسی

The work deals with the binding of 10-hydroxycamptothecin (HCPT) in the coating of so-called magnetoliposomes (MLs). The latter consist of nanometer-sized crystalline magnetite (Fe3O4) cores surrounded by a phospholipid bilayer, which for the present study is built up of either dipalmitoylphosphatidylcholine (DPPC) or mixtures of DPPC with dipalmitoylphosphatidylglycerol (DPPG) (DPPC/DPPG molar ratios of 4/1, 2/1, 1/1 and 1/3). Partitioning of HCPT in the ML coat significantly improves as the DPPG content in the ML coat increases, suggesting the importance of H-bridges between DPPG and HCPT in the absorption process. In contrast to the behaviour of ‘classical’ phospholipid membranes which expand upon drug binding, it is calculated that with the phospholipid bilayer immobilized on the Fe3O4 surface 2.6 ± 0.5 phospholipid molecules have to leave the membrane for insertion of 1 HCPT molecule. The potential of the ML-drug structures as promising theranostics (i.e. nanocolloids with both therapeutic and diagnostic features) is briefly discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 343, Issues 1–3, 10 July 2009, Pages 20–23
نویسندگان
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