کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5963234 1576125 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carotid atherosclerosis, silent ischemic brain damage and brain atrophy: A systematic review and meta-analysis
ترجمه فارسی عنوان
آترواسکلروز کاروتید، آسیب مغزی ایسکمیک مغزی و آتروفی مغزی: بررسی منظم و متاآنالیز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundThe widespread use of brain imaging has led to increased recognition of subclinical brain abnormalities, including white matter hyperintensities (WMH) and silent brain infarctions (SBI), which have a vascular origin, and have been associated to a high risk of stroke, disability and dementia. Carotid atherosclerosis (CA) may be causative in the development of WMH, SBI and eventually brain atrophy. Aim of the present systematic review and meta-analysis was to assess the existing evidence linking CA to WMH, SBI and brain atrophy.MethodsThe relation between CA and WMH, SBI and brain atrophy was investigated through the systematic search of online databases up to September 2015 and manual searching of references and related citations. Pooled estimates were calculated by random-effects model, using restricted maximum likelihood method with inverse variance weighting method.ResultsOf the 3536 records identified, fifteen were included in the systematic review and 9 were found to be eligible for the meta-analysis. CA was significantly associated with the presence of WMH (Odds Ratio, OR 1.42, confidence interval, CI 1.22-1.66, p < 0.0001) and of SBI (OR 1.89, CI 1.46-2.45, p < 0.0001). No meta-analysis could be performed for the relation between CA and brain atrophy due to the lack of suitable studies.ConclusionsCA was found to be associated to WMH and SBI. While no causative association can be inferred from the available data, the presence of carotid plaque may be considered a significant risk factor for subclinical cerebral damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 223, 15 November 2016, Pages 681-687
نویسندگان
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