|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5985767||1178779||2015||11 صفحه PDF||سفارش دهید||دانلود رایگان|
- Plant sterol supplementation reduces LDL-C in â¼10%.
- Statins by reducing cholesterol synthesis can increase cholesterol absorption.
- Plant sterols added to atorvastatin or to atorvastatin/ezetimibe further reduced LDL-C.
- Higher intestinal sterol absorption includes those treated with statins or statin plus ezetimibe.
- Phytosterols has been recommended as an adjunct to pharmacologic therapy to achieve lipid targets.
ObjectivePlant sterol (PS) supplementation has been widely used alone or combined with lipid-lowering therapies (LLTs) to reduce low-density lipoprotein (LDL) cholesterol. The effects of PS added to high-intensity LLT are less reported, especially regarding the effects on cholesterol synthesis and absorption.MethodsA prospective, randomized, open-label study, with parallel arms and blinded end points was designed to evaluate the effects of addition of PS to LLT on LDL cholesterol, markers of cholesterol synthesis, and absorption. Eighty-six patients of both genders were submitted to a 4-wk run-in period with atorvastatin 10Â mg (baseline). Following, subjects received atorvastatin 40Â mg, ezetimibe 10Â mg, or combination of both drugs for another 4-wk period (phase I). In phase II, capsules containing 2.0Â g of PSs were added to previous assigned treatments for 4Â wk. Lipids, apolipoproteins, plasma campesterol, Î²-sitosterol, and desmosterol levels were assayed at all time points. Within and between-group analyses were performed.ResultsCompared with baseline, atorvastatin 40Â mg reduced total and LDL cholesterol (3% and 22%, respectively, PÂ <Â .05), increased Î²-sitosterol, campesterol/cholesterol, and Î²-sitosterol/cholesterol ratios (39%, 47%, and 32%, respectively, PÂ <Â .05); ezetimibe 10Â mg reduced campesterol and campesterol/cholesterol ratio (67% and 70%, respectively, PÂ <Â .05), and the combined therapy decreased total and LDL cholesterol (22% and 38%, respectively, PÂ <Â .05), campesterol, Î²-sitosterol, and campesterol/cholesterol ratio (54%, 40%, and 27%, PÂ <Â .05). Addition of PS further reduced total and LDL cholesterol by â¼7.7 and 6.5%, respectively, in the atorvastatin therapy group and 5.0 and 4.0% in the combined therapy group (PÂ <Â .05, for all), with no further effects in absorption or synthesis markers.ConclusionsPS added to LLT can further improve lipid profile, without additional effects on intestinal sterol absorption or synthesis.
Journal: Journal of Clinical Lipidology - Volume 9, Issue 4, JulyâAugust 2015, Pages 542-552