Anti-inflammatory activity of chitosan nanoparticles carrying NF-κB/p65 antisense oligonucleotide in RAW264.7 macropghage stimulated by lipopolysaccharide

Brief: Chitosan NPs could efficiently delivery NF-κB/p65 antisense oligonucleotide into the cytoplasm and nucleus of macrophages, and then inhibit the NF-κB/p65 gene translation and expression, which at last suppress downstream production of inflammatory factors including TNF-ɑ, IL-1 and IL-6 in LPS stimulated RAW264.7 macrophages.