Multi-drug delivery system based on alginate/calcium carbonate hybrid nanoparticles for combination chemotherapy

- A facile strategy to prepare nano drug carriers for combination chemotherapy was developed.
- Alginate/CaCO3 hybrid nanoparticles for co-delivery of multiple types of drugs were prepared.
- Both hydrophobic and hydrophilic drugs can be loaded in the nanoparticles efficiently.
- Dual drug loaded nanoparticles exhibited significantly enhanced tumor cell inhibitory effect.
- The nanoparticles have promising applications in combination chemotherapy.