کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5996485 1180673 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal obesity regulates gene expression in the hearts of offspring
ترجمه فارسی عنوان
چاقی مادر باعث تنظیم بیان ژن در قلب فرزندان می شود
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Taste receptors have recently been identified in the heart.
- We examined effects of maternal obesity & exercise on rat cardiac gene expression.
- Maternal obesity reduced cardiac bitter but not umami taste receptors.
- Beta adrenoceptor 1a was decreased by maternal obesity.
- Maternal exercise did not affect taste receptor expression.

Background and aimsGrowing evidence suggests maternal obesity leads to adverse outcomes for offspring, including increased cardiovascular disease (CVD). Alterations in taste preferences of offspring from mothers consuming a high fat diet (HFD) have also been reported. Given recent reports describing cardiac taste receptors, we examined whether the expression of umami and bitter taste receptors is modulated by maternal obesity, and compared this with the physiological challenge of maternal exercise.Methods and resultsFemale Sprague-Dawley rats were fed chow (C) or HFD (F) and half of each were provided with a running wheel to enable voluntary exercise (CE or FE), the others remaining sedentary (CS or FS). Two pups from each mother were killed at postnatal day 19.Both lean and obese dams undertook similar amounts of exercise (8.1 ± 2.4 vs 5.1 ± 1.5 km). Maternal obesity increased offspring body weight, adiposity, net and weight-corrected heart ventricle weight, with no effect of exercise. Maternal obesity also increased offspring plasma leptin concentrations, which were normalised by maternal exercise. Cardiac ventricle mRNA expression of bitter taste receptors, β-adrenoceptor (Adrbk1) and angiotensin II receptor type 1a (Agtr1a) were significantly decreased in response to maternal obesity, with maternal exercise decreasing Agtr1a in FE offspring. No changes in umami receptors were observed. FTO mRNA expression was down-regulated by maternal HFD with an up-regulation in offspring of CE mothers.ConclusionMaternal obesity affected the expression of bitter taste receptors and other genes in the heart ventricle, potentially implicating these genes in the development of CVD associated with maternal obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 25, Issue 9, September 2015, Pages 881-888
نویسندگان
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