کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
600101 | 1454295 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Physicochemical and biological evaluation of poly(ethylene glycol) methacrylate grafted onto poly(dimethyl siloxane) surfaces for prosthetic devices Physicochemical and biological evaluation of poly(ethylene glycol) methacrylate grafted onto poly(dimethyl siloxane) surfaces for prosthetic devices](/preview/png/600101.png)
• Poly(dimethyl siloxane) (PDMS) was successfully modified with PEGMA by surface-initiated atom transfer radical polymerization (ATRP).
• Modified surfaces showed a hydrophilic character with water contact angles around 60°.
• Bacterial adhesion onto the modified surfaces of Streptococcus salivarius GB 24/9 and Staphylococcus aureus GB 2/1 was inhibited by 81–94%, respectively.
• Modified surfaces showed no evidence of cytotoxic effects on human skin fibroblasts cultures.
Poly(dimethyl siloxane) (PDMS) was surface-polymerized with poly(ethylene glycol)methacrylate (PEGMA) by surface-initiated atom transfer radical polymerization (SI-ATRP) in aqueous media at room temperature. Modification of the PDMS surface followed a three-step procedure: (i) PDMS surface hydroxylation by UV/ozone exposure, immediately followed by (ii) covalent attachment of the initiator, 1-trichlorosilyl-2-(chloromethylphenyl)ethane, onto the hydroxylated PDMS, via chemical vapor deposition; finally (iii) PDMS surface-polymerization of PEGMA by ATRP. Modified PDMS was characterized by water contact angle measurement, SEM, FTIR-ATR, and XPS. Results showed that modified surfaces had a hydrophilic character, given the water contact angles around 60°; FTIR-ATR and XPS analysis confirmed the presence of polymerized PEGMA on the surface of PDMS and the adhesion of Staphylococcus aureus GB 2/1 and Streptococcus salivarius GB 24/9 onto the modified surfaces was inhibited 94% and 81%, respectively. Finally, the modified PDMS showed no evidence of cytotoxic effects in in vitro assays using human skin fibroblasts.
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Journal: Colloids and Surfaces B: Biointerfaces - Volume 109, 1 September 2013, Pages 228–235