Promising prognostic markers of Preeclampsia: New avenues in waiting

- Early prediction of PE remains imperative for maternal and fetal surveillance
- Elusive pathophysiology and limited prognostic accuracy of known predictive markers
- Need for new markers for prediction of PE
- Recapitulation of prognostic potential of Corin, Copeptin, Microparticles and miRNA
- Large prospective studies required to assess clinical efficacy of these markers

Preeclampsia is a pregnancy related condition identified by hypertension and either proteinuria or end-organ dysfunction after 20th week of gestation and complicates 2-8% pregnancies worldwide. Enigmatic pathophysiology and multi-system involvement hinder accurate identification and clinical management of patients. Inadequate trophoblast invasion and subsequent inflammatory response have been implicated in the onset of PE. In absence of effective treatment of preeclampsia except delivery, recent research has been focused on identification of specific and sensitive biomarkers for early prediction of PE. Several angiogenic, anti-angiogenic, inflammatory, biophysical (mean arterial pressure and uterine artery Doppler) biomarkers, alone and in combination, have been proposed for prediction but limited predictive values have hindered their use in clinical settings. Current review summarizes some of relatively new biomarkers such as corin, copeptin, microparticles and miRNA, the prognostic efficiency of which are either analyzed in associated disorders or recently discovered.