کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6007181 | 1184767 | 2012 | 7 صفحه PDF | دانلود رایگان |

ObjectiveTo establish the value of thallium-201 single-photon emission computed tomography (201Tl-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs).MethodsWe studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (201Tl index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients.ResultsDuring a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7%). Based on Cox's proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, 201Tl index > 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a 201Tl index > 1.9 and a MIB-1 index > 6% were associated with short PFS.Conclusion201Tl SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high 201Tl uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination.
Journal: Clinical Neurology and Neurosurgery - Volume 114, Issue 3, April 2012, Pages 223-229