کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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600990 | 879929 | 2011 | 7 صفحه PDF | دانلود رایگان |
The development of advanced biomaterials and drug-delivery systems has had a significant impact on our ability to treat several diseases.A new study was performed on niosomal formulations obtained from a mixture of commercial surfactants (Tween 80 and Span 80) to be applied topically for the release of Capsaicin. Capsaicin is the pungent principle of red pepper and it has a variety of pharmacological actions on the cardiovascular, respiratory and nervous systems. Niosomal carriers were prepared using a particular ratio between surfactants, to obtain systems with a specific HLB (10,12,14) and characterized in terms of dimension, morphology and their drug entrapment efficiency. Niosomes were compared to microemulsions prepared from the same surfactants in the same ratio, to evaluate their possible use in transdermal drug delivery. As regards the in vitro percutaneous permeation of Capsaicin from both microemulsions and niosomal formulations, it was carried out using diffusion Franz cells. The results indicate that niosomes could better promote the transdermal delivery of Capsaicin, with respect to microemulsions, even if both carriers could be an effective vehicle for topical delivery of this drug.
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► We prepared niosomes for the topical delivery of Capsaicin.
► We compared the niosomal vesicles performances with microemulsions ones.
► We identified the optimal carrier for the percutaneous delivery of Capsaicin.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 87, Issue 2, 15 October 2011, Pages 333–339