کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6009937 | 1579830 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Paraneoplastic epilepsy
ترجمه فارسی عنوان
صرع پارانوپلاستی
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کلمات کلیدی
CASPR2LGIAutosomal dominant lateral temporal epilepsyANNAADPEAFExtreme delta brushADLTECRMPFBDSFDG-PETAEDsAMPAGADEPCalpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید آلفا آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکgamma-aminobutyric acid - اسید گاما آمینو بوتیریکFLAIR - اشتباهfluid-attenuated inversion recovery - بازیابی معکوس مایعfaciobrachial dystonic seizures - تشنج فیزیولوژیک دیستونیک18F-fluorodeoxyglucose positron emission tomography - توموگرافی انتشارات پوزیترون 18F-fluorodeoxyglucoseantiepileptic drugs - داروهای ضدصرع epilepsia partialis continua - صرع مداومEDB - محاسبهcollapsin response mediator protein - پروتئین متقابل پاسخ کلاپسینGABA - گاباGlutamate decarboxylase - گلوتامات دکربوکسیلاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Epilepsy can be a manifestation of paraneoplastic syndromes which are the consequence of an immune reaction to neuronal elements driven by an underlying malignancy affecting other organs and tissues. The antibodies commonly found in paraneoplastic encephalitis can be divided into two main groups depending on the target antigen: 1) antibodies against neuronal cell surface antigens, such as against neurotransmitter (N-methyl-d-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), gamma-aminobutyric acid (GABA)) receptors, ion channels (voltage-gated potassium channel (VGKC)), and channel-complex proteins (leucine rich, glioma inactivated-1 glycoprotein (LGI1) and contactin-associated protein-2 (CASPR2)) and 2) antibodies against intracellular neuronal antigens (Hu/antineuronal nuclear antibody-1 (ANNA-1), Ma2/Ta, glutamate decarboxylase 65 (GAD65), less frequently to CV2/collapsin response mediator protein 5 (CRMP5)). In this review, we provide a comprehensive survey of the current literature on paraneoplastic epilepsy indexed by the associated onconeuronal antibodies. While a range of seizure types can be seen with paraneoplastic syndromes, temporal lobe epilepsy is the most common because of the association with limbic encephalitis. Early treatment of the paraneoplastic syndrome with immune modulation/suppression may prevent the more serious potential consequences of paraneoplastic epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 61, August 2016, Pages 51-58
Journal: Epilepsy & Behavior - Volume 61, August 2016, Pages 51-58
نویسندگان
Anna Serafini, Rimas V. Lukas, Stephen VanHaerents, Peter Warnke, James X. Tao, Sandra Rose, Shasha Wu,