کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6010155 1579833 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploring human epileptic activity at the single-neuron level
ترجمه فارسی عنوان
بررسی فعالیت صرع انسان در سطح تک نورون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Epileptic activity of single neurons may precede the seizure by minutes.
- Seizure-related interactions between neurons show complex heterogeneous dynamics.
- Neurons in the penumbra maintain their spike stereotypy during the seizure.
- Cell loss correlates with changes in firing patterns and memory deficits.
- Seizure prediction based on single-neuron recordings is in its early stage.

Today, localization of the seizure focus heavily relies on EEG monitoring (scalp or intracranial). However, current technology enables much finer resolutions. The activity of hundreds of single neurons in the human brain can now be simultaneously explored before, during, and after a seizure or in association with an interictal discharge. This technology opens up new horizons to understanding epilepsy at a completely new level. This review therefore begins with a brief description of the basis of the technology, the microelectrodes, and the setup for their implantation in patients with epilepsy. Using these electrodes, recent studies provide novel insights into both the time domain and firing patterns of epileptic activity of single neurons. In the time domain, seizure-related activity may occur even minutes before seizure onset (in its current, EEG-based definition). Seizure-related neuronal interactions exhibit complex heterogeneous dynamics. In the seizure-onset zone, changes in firing patterns correlate with cell loss; in the penumbra, neurons maintain their spike stereotypy during a seizure. Hence, investigation of the extracellular electrical activity is expected to provide a better understanding of the mechanisms underlying the disease; it may, in the future, serve for a more accurate localization of the seizure focus; and it may also be employed to predict the occurrence of seizures prior to their behavioral manifestation in order to administer automatic therapeutic interventions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 58, May 2016, Pages 11-17
نویسندگان
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