کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6010494 | 1579838 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disruption of learning and long-term retention of prose passages in patients with focal epilepsy
ترجمه فارسی عنوان
اختلال در یادگیری و حفظ طولانی مدت پروسه ها در بیماران مبتلا به صرع کانونی
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کلمات کلیدی
فراموشی طولانی مدت را تسریع کنید، صرع، حافظه کلامی، ضایعات هیپوکامپ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Recent investigations of accelerated long-term forgetting, a condition in which newly acquired memory is normal initially but decays rapidly over days or weeks, indicate that multiple factors might influence whether this phenomenon is seen in patients with epilepsy. Test-based differences such as learning condition or type of memory measure (e.g., recall vs recognition) as well as epilepsy variables (e.g., side, site, or frequency of epileptiform activity) may be important. The present study sought to characterize factors affecting learning and memory for prose passages in patients with focal epilepsy. We enrolled 21 patients with temporal lobe epilepsy, with and without hippocampal lesions, 11 patients with extratemporal epilepsy (ETE), and 29 healthy controls. Two matched passages were used to compare effects of initial learning condition (one exposure versus learning-to-criterion) on subsequent patterns of retention. Recall and recognition were tested at different delays (i.e., immediately, 30Â min, 24Â h, and 4Â days). Regression analyses and one-way ANOVAs indicated that having a left-hemisphere epileptic focus had a negative impact on learning, whilst presence of a hippocampal lesion (irrespective of side) was associated with deterioration in recall for intervals up to 24Â h postencoding. Learning condition affected patterns of memory decay in that the ETE group showed significant decline in recall between 24Â h and 4Â days only when stories were learned to criterion. In contrast with recall, no changes over time were evident in recognition memory, as patients with hippocampal lesions were impaired from 30Â min onward. Epilepsy variables other than side and site of epilepsy/lesion did not influence performance. In conclusion, the left hemisphere is involved in learning of prose material, and the hippocampus is involved in the consolidation of this material mainly for the first 24Â h. After this, cortical regions outside the hippocampus become important for recall.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 51, October 2015, Pages 104-111
Journal: Epilepsy & Behavior - Volume 51, October 2015, Pages 104-111
نویسندگان
Monica Ricci, Armin Mohamed, Greg Savage, Laurie A. Miller,