کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6010575 1579838 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thalamocortical connectivity is enhanced following functional hemispherotomy for intractable lateralized epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Thalamocortical connectivity is enhanced following functional hemispherotomy for intractable lateralized epilepsy
چکیده انگلیسی
Although developmental outcomes may improve following functional hemispherotomy for lateralized, catastrophic childhood epilepsy, the neuronal processes mediating these improvements are unknown. We report the case of a 14-year-old child with neurocognitive impairment who underwent functional hemispherotomy with longitudinal resting-state fMRI. Compared with preoperative fMRI, we report significantly more robust thalamo-default mode network connectivity on postoperative neuroimaging. Furthermore, we show decreased connectivity to nodes within the disconnected hemisphere, providing direct evidence that functional interactions are dependent upon structural connectivity. Since the vascular supply to these nodes remains intact, although they are disconnected from the remainder of the brain, these findings also confirm that blood-oxygen level dependent oscillations are driven primarily by neuronal activity. The current study highlights the importance of thalamocortical interactions in the understanding of neural oscillations and cognitive function, and their impairment in childhood epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 51, October 2015, Pages 281-285
نویسندگان
, , , , , , , , , , ,