کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6010814 1579839 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy
ترجمه فارسی عنوان
اعتبار سنجی تست های تشخیصی برای اختلال افسردگی در صرع لوب صرع مزیال مقاوم به دارو
کلمات کلیدی
صرع لوب لثه مزیال مقاوم در برابر دارو، اسکلروز هیپوکمپ، اختلال افسردگی، آزمایش های تشخیصی دقت تشخیصی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- We analyzed diagnostic tests for depressive disorder in drug-resistant MTLE.
- MTLE seems to be more associated with depression than other types of epilepsy.
- BDI and HADS total are valid diagnostic tests for depressive disorder in MTLE.
- Both showed acceptable specificity and PPV for this type of study.

PurposeThis study aimed to evaluate the diagnostic accuracy of the Hamilton Rating Scale for Depression (HRSD), the Beck Depression Inventory (BDI), the Hospital Anxiety and Depression Scale (HADS), and the Hospital Anxiety and Depression Scale-Depression subscale (HADS-D) as diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).MethodsOne hundred three patients with drug-resistant MTLE-HS were enrolled. All patients underwent a neurological examination, interictal and ictal video-electroencephalogram (V-EEG) analyses, and magnetic resonance imaging (MRI). Psychiatric interviews were based on DSM-IV-TR criteria and ILAE Commission of Psychobiology classification as a gold standard; HRSD, BDI, HADS, and HADS-D were used as psychometric diagnostic tests, and receiver operating characteristic (ROC) curves were used to determine the optimal threshold scores.ResultsFor all the scales, the areas under the curve (AUCs) were approximately 0.8, and they were able to identify depression in this sample. A threshold of ≥ 9 on the HRSD and a threshold of ≥ 8 on the HADS-D showed a sensitivity of 70% and specificity of 80%. A threshold of ≥ 19 on the BDI and HADS-D total showed a sensitivity of 55% and a specificity of approximately 90%. The instruments showed a negative predictive value of approximately 87% and a positive predictive value of approximately 65% for the BDI and HADS total and approximately 60% for the HRSD and HADS-D.ConclusionsHRSD ≥ 9 and HADS-D ≥ 8 had the best balance between sensitivity (approximately 70%) and specificity (approximately 80%). However, with these thresholds, these diagnostic tests do not appear useful in identifying depressive disorder in this population with epilepsy, and their specificity (approximately 80%) and PPV (approximately 55%) were lower than those of the other scales. We believe that the BDI and HADS total are valid diagnostic tests for depressive disorder in patients with MTLE-HS, as both scales showed acceptable (though not high) specificity and PPV for this type of study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 50, September 2015, Pages 61-66
نویسندگان
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