کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6011084 1579842 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autism spectrum disorder and epilepsy: Disorders with a shared biology
ترجمه فارسی عنوان
اختلالات طیف اوتیسم و ​​صرع: اختلالات با زیست شناسی مشترک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- ASD and various forms of epilepsy commonly co-occur.
- A number of new genetic discoveries suggest shared biology for both disorders.
- Several screening and diagnostic tools are available for clinicians.

There is an increasing recognition of clinical overlap in patients presenting with epilepsy and autism spectrum disorder (ASD), and a great deal of new information regarding the genetic causes of both disorders is available. Several biological pathways appear to be involved in both disease processes, including gene transcription regulation, cellular growth, synaptic channel function, and maintenance of synaptic structure. We review several genetic disorders where ASD and epilepsy frequently co-occur, and we discuss the screening tools available for practicing neurologists and epileptologists to help determine which patients should be referred for formal ASD diagnostic evaluation. Finally, we make recommendations regarding the workflow of genetic diagnostic testing available for children with both ASD and epilepsy.This article is part of a Special Issue entitled “Autism and Epilepsy”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 47, June 2015, Pages 191-201
نویسندگان
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