کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6012501 1579858 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brief CommunicationRole of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Brief CommunicationRole of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice
چکیده انگلیسی

This study was designed to investigate the role of experimental febrile seizures in the induction of generalized clonic seizures and the involvement of heat-sensitive channel TRPV1. Pentylenetetrazol-induced clonic seizure was used as the seizure model, and Trpv1 gene knock-out and wild-type C57/BL6 mice were used as experimental subjects. Electroencephalograph and seizure behavior were recorded for the evaluation of the severity of seizures.Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures. Trpv1 gene deficiency decreased the properties of generalized clonic seizure. The intensity of experimental febrile seizures reduced the threshold to generalized clonic seizure, and Trpv1 gene deficiency decreased the susceptibility to PTZ-induced seizures following early-life hyperthermia challenges in mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 31, February 2014, Pages 276-280
نویسندگان
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