Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres

► Polysaccharide nanocrystals were firstly introduced into alginate microspheres. ► Mechanical strength and drug release behavior were enhanced and regulated. ► Nanocrystals increased the stability of the crosslinked network structure. ► Release kinetics and transport mechanisms were analyzed and recognized.