کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6012739 1185906 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparing the effects of cortical resection and vagus nerve stimulation in patients with nonlesional extratemporal epilepsy
ترجمه فارسی عنوان
مقایسه اثرات رزکسیون قشر و تحریک عصب واگ در بیماران مبتلا به صرع اضطراب غیرخواب
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- First study comparing resection and VNS in nonlesional extratemporal epilepsy
- Both procedures had significant effect on seizures and did not differ significantly.
- McHugh classification did not show significant differences between procedures.
- We revealed a significantly higher number of Engel I + II patients in resections.
- Both procedures lead to significant decrease in admission costs.

The main purpose of this retrospective study was to compare the effects of resective surgery (RESgr-26 patients) and vagus nerve stimulation (VNSgr-35 patients) on seizure frequency (2 and 5 years after surgery) in patients with nonlesional extratemporal epilepsy (NLexTLE). We analyzed hospital admission costs directly associated with epilepsy (HACE) in both groups at the same follow-up. The decrease in seizure frequency from the preoperative levels, in both VNSgr and RESgr, was statistically significant (p < 0.001). The seizure frequency reduction did not differ significantly between the follow-up visits for either group (p = 0.221 at 2 years and 0.218 at 5 years). A significantly higher number of Engel I and Engel I + II patients were found in RESgr than in VNSgr at both follow-up visits (p = 0.04 and 0.007, respectively). Using McHugh classification, we did not find statistically significant differences between both groups at both follow-up visits. Hospital admission costs directly associated with epilepsy/patient/year in both RESgr and VNSgr dropped significantly at 2- and 5-year follow-up visit and this reduction was not statistically different between RESgr and VNSgr (p = 0.232).Both VNS and resective surgery cause comparably significant seizure reduction in NLexTLE. Resective surgery leads to a greater number of patients with excellent postoperative outcome (Engel I + II). The HACE reduction is statistically comparable between both groups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 28, Issue 3, September 2013, Pages 474-480
نویسندگان
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