کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6013340 | 1185911 | 2012 | 7 صفحه PDF | دانلود رایگان |
We followed four patients with infrequent convulsive seizures for four to 10Â years, with periodic EEGs and neuropsychological tests. All four had bursts of frontally predominant, bilaterally synchronous 1.5-3âHz spike or polyspike and slow-wave discharges (SWDs) that initially comprised 15% to 88% but were reduced to 5% or less of total EEG time with appropriate antiepileptic drugs. Case 1 showed a 30-point improvement in his verbal WAISâR score and Case 4 a 21-point improvement in his performance WAISâR score, over nine- and five-year periods, respectively, with normalization of frontal executive function. Cases 2 and 3 showed no improvement in frontal executive dysfunction despite being free of SWDs for nine and five years, respectively. These patients had variable degrees of epileptic encephalopathy and subclinical SWDs. They illustrate the importance of minimizing the occurrence of SWDs with appropriate antiepileptic drugs and long-term monitoring with neuropsychological tests because chronic cognitive deficits are potentially reversible.
⺠Adults with generalized epilepsy may have frequent bilateral spike-wave discharges. ⺠These spike-wave discharges may be associated with chronic cognitive deficits. ⺠The chronic cognitive deficits are an adult form of epileptic encephalopathy. ⺠This chronic encephalopathy may be reversed with suppression of the discharges. ⺠It may be years before maximal improvement in cognition occurs.
Journal: Epilepsy & Behavior - Volume 25, Issue 3, November 2012, Pages 442-448