Should antidepressant drugs of the selective serotonin reuptake inhibitor family be tested as antiepileptic drugs?

► Serotonin has been shown to play an important pathogenic role in epilepsy. ► Decreased CNS serotonergic activity has been shown in animals models of epilepsy. ► Decreased binding of the 5HT-1A receptor has been identified in humans with TLE. ► SSRIs exert antiepileptic activity in several animal models of epilepsy.