Validation of the Spanish version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)

IntroductionTo translate and validate into Spanish (Spain) the screening instrument of major depressive episodes (MDEs), Neurological Disorders Depression Inventory in Epilepsy (NDDI‐E), in patients with epilepsy.MethodsA total of 121 outpatients, aged 18 years and older, with a diagnosis of epilepsy were included. The diagnosis of a current major depressive episode (MDE) was established with the Mini International Neuropsychiatric Interview (MINI).ResultsA diagnosis of current MDE was established in 20% of the patients with the MINI. Receiver operator characteristics (ROC) analysis showed an area under the curve of 0.89, with an internal consistency of 0.78. At a cutoff score > 13, 22% of patients were considered to suffer from MDE with the NDDI-E (sensitivity: 84%; specificity: 78%; positive predictive value: 64.7%; and negative predictive value: 92.2%).DiscussionThe Spanish-Spain version of the NDDI-E appears to be a good screening instrument to identify MDE.

Highlights► The more accurate value for determining MDE was > 13 with a S 84 and E 78. ► The presence of depression (20%) was comparable to other population-based studies. ► One quarter (24%) of the patients in our study endorsed suicidal ideation. ► In our study, more than half of the patients suffering from MDE are not being treated. ► The Spanish version of NDDI-E is a useful tool for detecting depression in epilepsy.