کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6013543 1185915 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The transient effect of interictal spikes from a frontal focus on language-related gamma activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The transient effect of interictal spikes from a frontal focus on language-related gamma activity
چکیده انگلیسی
Interictal spike activity arising from an epileptic focus may cause transient subclinical changes in language function. We retrospectively studied four patients with a seizure focus of the left frontal lobe who underwent language mapping via electrocorticography. In three patients, we could group language task trials into 'spike' and 'non-spike' trials, based upon occurrence of spikes arising from the seizure onset zone during presentation of question stimuli. In one patient, we demonstrated a reduction in language-related gamma activity (80-100 Hz) at one dorsal superior frontal site outside the seizure onset zone; reduction in mean peak amplitude of 58.4% of baseline reference (95% C.I.: 31.6% to 85.1%). This site was located near the seizure onset zone and was associated with the greatest spike rate among sites of similar function. This is the first preliminary study to show an effect of interictal spikes upon language-related gamma activity of the lateral frontal lobe.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 24, Issue 4, August 2012, Pages 497-502
نویسندگان
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