The gelastic seizures-hypothalamic hamartoma syndrome: Facts, hypotheses, and perspectives

► Hypothalamic hamartoma (HH) may be associated with a catastrophic epilepsy. ► Epileptogenicity of HH is due to GABAergic, spontaneously firing neurons. ► Surgical ablation of HH or radiosurgery can reverse encephalopathy. ► We review the topic of gelastic seizures-hypothalamic hamartoma.