کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6013771 | 1185922 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy
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کلمات کلیدی
Depression - افسردگیEpilepsy - بیماری صرعMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیMood - خُلقtemporal lobe epilepsy - صرع لوب تمپورالcortical thickness - ضخامت قشرFreesurfer - فریزرفرorbitofrontal cortex - قشر اوربیتوفرنتالMorphometry - مورفومتریBDI, Beck Depression Inventory - پرسشنامه افسردگی بک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy](/preview/png/6013771.png)
چکیده انگلیسی
Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 23, Issue 1, January 2012, Pages 64-67
Journal: Epilepsy & Behavior - Volume 23, Issue 1, January 2012, Pages 64-67
نویسندگان
Tracy Butler, Karen Blackmon, Carrie R. McDonald, Chad Carlson, William B. Barr, Orrin Devinsky, Ruben Kuzniecky, Jonathan DuBois, Jacqueline French, Eric Halgren, Thomas Thesen,