Biperiden for treatment of somnambulism in adolescents and adults with or without epilepsy: Clinical observations

► Sleepwalking may lead to serious injuries and require treatment. ► We studied the use of biperiden, an anticholinergic drug, on sleepwalking. ► Biperiden use was associated with remission/reduction of sleepwalking. ► Biperiden may be useful for treatment of sleepwalking, if needed. ► Biperiden may affect the putatively cholinergic mechanism of sleepwalking.