کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6013892 1185926 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased language laterality in tuberous sclerosis complex:: A relationship between language dominance and tuber location as well as history of epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Decreased language laterality in tuberous sclerosis complex:: A relationship between language dominance and tuber location as well as history of epilepsy
چکیده انگلیسی

Nearly 90% of patients with tuberous sclerosis complex (TSC) have epilepsy. Epilepsy surgery can be considered, which often requires a presurgical assessment of language lateralization. This is the first study to investigate language lateralization in TSC patients using magnetoencephalography. Fifteen patients performed a language task during magnetoencephalography recording. Cerebral generators of language-evoked fields (EF) were identified in each patient. Laterality indices (LI) were computed using magnetoencephalography data extracted from the inferior frontal as well as middle and superior temporal gyri from both hemispheres between 250 and 550 ms. Source analysis demonstrated a fusiform gyrus activation, followed by an activation located in the basal temporal language area and middle and superior temporal gyri responses, ending with an inferior frontal activation. Eleven patients (73.3%) had left‐hemisphere language dominance, whereas four patients (26.7%) showed a bilateral language pattern, which was associated with a history of epilepsy and presence of tubers in language-related areas.

► First study to investigate language lateralization in TSC patients using MEG. ► Decreased language lateralization is associated with TSC. ► Bilateral language associated with a history of epilepsy and tubers in language areas. ► Decreased language dominance proportional to the lesion burden in language areas.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 25, Issue 1, September 2012, Pages 36-41
نویسندگان
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