Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae)

► Parawixin 10 blocks generalized seizures induced with kainic acid, N-methyl-D-aspartate, and pentylenetetrazole. ► Addition of Parawixin 10 to synaptosomes from rat cerebral cortices increases L-glutamate uptake. ► Parawixin 10 does not induce locomotor alterations.