Differential neuroprotection by A1 receptor activation and A2A receptor inhibition following pilocarpine-induced status epilepticus

► Adenosine A1 receptor is neuroprotective. ► SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) has an anticonvulsant effect. ► SCH58261 is neuroprotective only if combined with (R(−)-N6-(2)-phenylisopropyl adenosine.