کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6013951 | 1185927 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anticonvulsant and depressant effects of aqueous extracts of Carum copticum seeds in male rats Anticonvulsant and depressant effects of aqueous extracts of Carum copticum seeds in male rats](/preview/png/6013951.png)
In this study, the effects of aqueous extracts of Carum copticum seeds (CCS) were evaluated in kindling models of epilepsy. Additionally, the sedative and anxiolytic effects of the extract were assessed. For pentylenetetrazole (PTZ) kindling, rats received a subconvulsant dose of PTZ (40Â mg/kg, ip) every second day and seizure stages were recorded. CCS aqueous extract (200, 400, or 600Â mg/kg, ip) was injected 30 minutes prior to each PTZ injection. In electrical kindling, bipolar stimulating and monopolar recording electrodes were implanted stereotaxically in the right basolateral amygdala of male Sprague-Dawley rats. After kindling, the effect of aqueous extracts of CCS (200, 400, or 600Â mg/kg, ip) on afterdischarge duration, duration of rearing, forelimb clonus, and loss of equilibrium (stage 5 seizure), and latency to the onset of bilateral forelimb clonus were measured. The sedative and the anxiolytic effects of CCS extracts were evaluated in an open-field apparatus and elevated plus maze, respectively. The results indicate that aqueous extracts of CCS have a significant anticonvulsant effect. Different doses of extract significantly delayed the incidence of every seizure stage in the PTZ model of kindling. Moreover, CCS extract (400 and 600Â mg/kg, ip) suppressed afterdischarge duration, latency to the onset of bilateral forelimb clonus, and stage 5 seizure in the electrical kindling model. These results suggest that CCS extract has remarkable antiepileptic and central depressant effects.
⺠Corum copticum seeds are used as an antiepileptic and depressant factor in traditional medicine in Iran. ⺠Corum copticum seed aqueous extracts exhibited antiepileptic and depressant effects in two experimental models. ⺠This study indicates that this extract has significant antiepileptic and depressant effects in kindling models of epilepsy.
Journal: Epilepsy & Behavior - Volume 22, Issue 2, October 2011, Pages 220-225