Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress

► The effect of phenytoin, CoQ10 on seizures severity and oxidative markers in epilepsy. ► The effect of phenytoin, CoQ10 for two weeks on behavior and oxidative markers. ► CoQ10 potentiated the antiepileptic effects of phenytoin and reduced oxidative stress. ► It ameliorated oxidative stress and cognitive impairment of chronic phenytoin therapy.