Obsessive-compulsive disorder in chronic epilepsy

► Obsessive-compulsive disorder occurs in ~25% of patients with temporal lobe epilepsy. ► Neurobiological factors indicate abnormalities in frontal-thalamic-striatal-cingulate-frontal circuits. ► Damage or surgery along these circuits may produce or reduce obsessive-compulsive disorder in temporal lobe epilepsy. ► Recent treatment of obsessive-compulsive disorder with invasive deep brain stimulation is controversial.