Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats

► Heart rate responses were measured in rats submitted to the electric amygdala kindling model. ► Ictal bradycardia occurred and increased with progression of the kindling stages. ► Rebound tachycardia occurred after repeated stage 5 seizures. ► It is concluded that seizure recurrence alters cardiac autonomic modulation, which could predispose to sudden unexpected death in epilepsy.