Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid

► N-Methoxy-valnoctamide has better anticonvulsant activity than valproic acid. ► The ED50 values of N-methoxy-valnoctamide in mice were 142 mg/kg in the maximal electroshock test, 70 mg/kg in the subcutaneous metrazol test, and 35 mg/kg in the 6-Hz test. ► The ED50 of N-methoxy-valnoctamide in rats in the subcutaneous metrazol test was 36 mg/kg and its protective index (TD50/ED50) was > 5.5.