Rational polytherapy with lacosamide in clinical practice: Results of a Spanish cohort analysis RELACOVA

► Observational study in patients with partial-onset epilepsy in a real-world setting. ► Lacosamide is effective for patients with partial-onset seizures in a real world setting. ► This study supports rational polytherapy. ► Combination of lacosamide and a non-sodium channel blocker is associated with a high efficacy.