کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6014599 | 1185936 | 2012 | 7 صفحه PDF | دانلود رایگان |

The mismatch negativity (MMN) is an electrophysiological trace of change detection, measured by electroencephalography (EEG), and is a reliable marker for pre-attentive auditory sensory memory. We used a phonetic oddball paradigm in patients with temporal lobe epilepsy (TLE) to elicit the MMN response at fronto-central sites and the mismatch positivity (MMP) response at mastoid sites. The MMN in 26 patients was compared with that of 26 age- and gender-matched healthy control participants. Electroencephalography responses were recorded during the presentation of speech sounds: the vowels 'a' and 'o' in alternation. Average waveforms were obtained for standard and deviant trials. We found that the MMP response at bilateral mastoid sites was reduced, whereas the MMN response at fronto-central sites did not change significantly. These results support the view that the MMN is generated by separable sources in the frontal and temporal lobes and that these sources are differentially affected by TLE.
⺠We describe the phonetic mismatch negativity (MMN) in temporal lobe epilepsy (TLE). ⺠In TLE, MMN was diminished at mastoid sites, while MMN at Fz and Cz showed no change. ⺠Phonetic MM potential at mastoid site may be useful to evaluate temporal function. ⺠Our results support the view that MMN is generated by multiple independent sources.
Journal: Epilepsy & Behavior - Volume 23, Issue 3, March 2012, Pages 335-341