کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6014599 1185936 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mismatch negativity for speech sounds in temporal lobe epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Mismatch negativity for speech sounds in temporal lobe epilepsy
چکیده انگلیسی

The mismatch negativity (MMN) is an electrophysiological trace of change detection, measured by electroencephalography (EEG), and is a reliable marker for pre-attentive auditory sensory memory. We used a phonetic oddball paradigm in patients with temporal lobe epilepsy (TLE) to elicit the MMN response at fronto-central sites and the mismatch positivity (MMP) response at mastoid sites. The MMN in 26 patients was compared with that of 26 age- and gender-matched healthy control participants. Electroencephalography responses were recorded during the presentation of speech sounds: the vowels 'a' and 'o' in alternation. Average waveforms were obtained for standard and deviant trials. We found that the MMP response at bilateral mastoid sites was reduced, whereas the MMN response at fronto-central sites did not change significantly. These results support the view that the MMN is generated by separable sources in the frontal and temporal lobes and that these sources are differentially affected by TLE.

► We describe the phonetic mismatch negativity (MMN) in temporal lobe epilepsy (TLE). ► In TLE, MMN was diminished at mastoid sites, while MMN at Fz and Cz showed no change. ► Phonetic MM potential at mastoid site may be useful to evaluate temporal function. ► Our results support the view that MMN is generated by multiple independent sources.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 23, Issue 3, March 2012, Pages 335-341
نویسندگان
, , , , , , , , , ,