Presurgical epilepsy localization with interictal cerebral dysfunction

► The roles of FDG PET and neuropsychological evaluation in planning epilepsy surgery are reviewed. ► Interictal FDG PET can support temporal lobe resection when MRI is normal. ► Interictal FDG PET can prognosticate seizure outcome of surgery. ► Neuropsychological evaluation can assist in selecting surgical candidates. ► Neuropsychological evaluation can prognosticate cognitive outcome of surgery.